Therefore, alternative rapid POC diagnostic kits are extremely desired.īiosensors are simple, real-time, and effective devices capable of detecting various infectious diseases 4. Due to the fast spread of the virus and the consequent high infectivity and mortality rates, it is vital to innovate fast-response, low-cost, and user-friendly SARS-CoV-2 detection techniques 2. Furthermore, this laboratory-based technique is time-consuming, expensive, and requires advanced tools and skilled clinical lab technicians 3. Though this method has sufficient sensitivity, it comes with roughly ten percent false-negative or false-positive results 2. The World Health Organization (WHO) has recommended PCR to be considered as the golden standard method for coronavirus detection and COVID-19 diagnosis. There are several routine techniques being used to detect the virus, including polymerase chain reaction (PCR), qRT-PCR, RT-LAMP, CRISPR, and NGS (next-generation genome sequencing) 1. The virus genome is the most potent biomarker used in most point-of-care (POC) diagnostic kits. Since then, various biomarkers have been used to diagnose the disease. Although nowadays vaccines are being used globally to harness the epidemic, their efficiency is not ideal, and the pandemic is yet taking victims. It has been more than two years since the outbreak of the SARS-CoV-2 virus in 2019 and the announcement of the Covid-19 Pandemic. This is the first time harmonic signatures are used to detect SARS-CoV-2 in swab samples. Our early results demonstrate that this method can detect the virus in solution. The developed system is able to distinguish between positive and negative samples with 5–10 dBc (decibels relative to the carrier) higher third harmonic ratios in positive samples, in agreement with the computational estimation. Computational modeling of harmonic production supports the hypothesis of ion channels (the E-protein) with nonlinear current–voltage characteristics being present on the virus envelope as a possible origin of harmonics. A known current is injected into the virus sample suspension, and the biomarker is the third harmonic detected in the power spectrum of the recorded signal. Here we present a new diagnostic method based on nonlinear dielectric spectroscopy to detect the presence of the SARS-CoV-2 virus in swab samples. The coronavirus disease caused by the SARS-CoV-2 virus has affected people worldwide for more than two years.

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